11/8/2023 0 Comments Wai pikao pikao![]() It’s the perfect time to put your farmer’s market haul to use! What food should I bring? This hike is pretty short so you’ll be fine with snacks unless you plan on having a picnic lunch (or dinner).If it happens to be wet, a rare occurrence, then I’d suggest sneakers, sandals with straps, or bare feet! In terms of footwear anything would work just fine so long as it’s dry. What should I bring? Sun protection, water, plus swim essentials if you plan on taking a dip at the end (*do not swim if you have any open wounds as the fresh water on Kauai potentially exposes you to Leptospirosis).The trail becomes extremely muddy and rather slippery when wet. Otherwise, it’s a perfectly beautiful hike any time of day so long as it’s not raining or there haven’t been recent heavy rains. When is the best time to go? The earlier the better if you prefer to explore with less people around.You’ll follow this road for about 3/4 of a mile, turning right at the fork until you reach the final lot where the trail begins. ![]() You’ll also notice a NASA satellite tracking station next-door, park in this area unless you have 4WD and can carry on down the dirt road. As you’re headed up into the park, this intersection (and the start of the dirt road) is marked by a large Koke’e State Park sign on the righthand side of the highway. What is the parking situation like? The trailhead we always start from is down a dirt road that begins just past mile 14 on the highway.Where are Waipo’o Falls? Waipo’o Falls are located in the heart of Waimea Canyon and you can see them from several points along the highway heading up to Koke’e. ![]() They love pretending that they’re chasing dinosaurs and have also designated one particular boulder towards the end as their “pirate ship.” In other words, the trail has a variety of interesting features that a child’s imagination can run away with and plenty of fantastic canyon views. At four and six years old, our boys can do the majority of this hike on their own as the trail mostly winds through a beautiful forest. This is a popular family-friendly trail that is suitable for children of all ages (and babies in carriers). Why Waipo’o Falls? It’s a quick 1.5 mile hike to the get back behind the top of the falls where mini 15-foot falls and a small swimming hole await.It is 800 feet tall and this hike leads you to the top tier of it! Waipo’o Falls refers to the waterfall that is the most photographed feature of Waimea Canyon.Piao has built a collaborative and cohesive team that broadly addresses how early insults, such as maternal inflammation and hypoxic-ischemic injuries affect fetal and neonatal brain development.Favorite picnic spot on Waipo’o Falls Trail Blooming Trees along the Waipo’o Falls Trail Racing along the Waipo’o Falls Trail Exploring the end of the Waipo’o Falls Trail Piao was recruited from Harvard Medical School / Boston Children's Hospital to UCSF to direct the Newborn Brain Research Institute and assume the Benioff Professorship in Children’s Health. This basic science also provides foundational knowledge for drug discoveries in targeting aGPCRs, the second largest human GPCR family. Piao undertook a pioneering role in deorphanizing aGPCRs and revealing mechanisms underlying aGPCR-mediated cell-cell and cell-matrix interactions. Piao’s research team has steadily uncovered a remarkable diversity of cell type- and ligand-specific functions of GPR56 during various stages of brain development and homeostasis, including cortical patterning, central nervous system myelin formation and repair, and synaptic refinement. Following the thread of GPR56 biology also led to a vigorous bench research program. Over time, this discovery transformed our understanding of polymicrogyria and yielded a molecular diagnostic. Together, they discovered that germline loss-of-function mutations in the adhesion G-protein-coupled receptor (aGPCR) GPR56, also called ADGRG1, cause BFPP. Her research began by characterizing an autosomal recessive human brain malformation that she and her mentor Chris Walsh termed bilateral frontoparietal polymicrogyria (BFPP). ![]() Piao’s career follows the bedside-to-bench-to-bedside paradigm. Working in neonatal intensive care unit and laboratory, Dr. She received her PhD with Alan Bernstein from University of Toronto, before completing her Pediatric residency at NYU and Neonatology fellowship as well as a post-doctoral fellowship with Chris Walsh at Harvard Medical School. Piao is a physician-scientist with a focus in both neonatology and developmental neuroscience. ![]()
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